Daturine is a mixture of alkaloids obtained from Datura Stramonium, Linn. (N.O. Solanaceae). It consists chiefly of hyoscyamine, with a variable proportion of atropine. It occurs in white silky crystals.
Slightly soluble in water, but freely soluble in alcohol, ether, and chloroform.
Action and Uses.—Daturine has the same action as hyoscyamine, but is seldom given internally. For ophthalmic use it is prescribed as a mydriatic in the form of ointment. The alkaloid is dissolved in the ointment basis, usually soft paraffin, melted at a low temperature. Daturine sulphate, which occurs in minute white crystals, is readily soluble in water, and is used in the form of drops (0.5 per cent. solution) for the eyes; it is also prepared in the form of ophthalmic discs, combined with gelatin. In cases of poisoning by daturine, the stomach should be emptied and stimulants given.
Dose.—1/2 to 1 milligram (1/120 to 1/60 grain).
The British Pharmaceutical Codex, 1911, was published by direction of the Council of the Pharmaceutical Society of Great Britain.